Key To Resistance To Common Cancer Drug Could Be Variation Of Normal Protein

�Researchers at the Moores Cancer Center at the University of California, San Diego (UC SD) in La Jolla have establish evidence explaining why a common chemotherapy drug, cisplatin, may not always act for every cancer patient. They bear shown that when a variant version of a key protein that ordinarily causes cell death is active, patients may be resistant to the cancer-killing drug.



The scientists say that such findings, reported on-line this workweek in the journal Proceedings of the National Academy of Sciences, are authoritative to savvy how personalized therapies may be developed for patients.



In a series of experiments, Jean Wang, Ph.D., distinguished professor of medicine and Associate Director of Basic Research at the Moores UCSD Cancer Center, Richard Kolodner, Ph.D., professor of medicine at UC San Diego and Executive Director, Laboratory Science and Technology at the Ludwig Institute for Cancer Research and their co-workers found evidence that when a specific variant form of a so-called "mismatch repair" protein, PMS2, is active, cisplatin doesn't kill cancer cells the way it usually does. The cancer is, in effect, resistant to the drug.



As a quicken protein, PMS2 is crucial to fix mistakes in DNA that may occur during replication. It besides has a darker face, playing a role in instructing cells to kill themselves.



For example, Wang, Kolodner and their colleagues had previously shown that PMS2 is required for cisplatin to kill cancer cells, activating some other protein, p73, which in turn begins a cascade of steps leading to cell suicide. Since most cancer cell-killing therapies such as chemotherapy and radiation take advantage of this process, the team wanted to better understand how cancer cells might bilk such self-annihilation instructions, rendition the therapy ineffective.



Defects in such mismatch repair genes and proteins can gain cancer endangerment, particularly for hereditary colon cancer. The researchers knew that the PMS2 cistron had at least 12 different forms in man. In studies on black eye cells wanting PMS2, they tested several different variations of the human PMS2 protein, for the most part display that PMS2 indeed hypersensitized cells to cisplatin, causing cell felo-de-se. They last found that one variant, PMS2 (R20Q), failed to activate p73 and bring about cubicle death in response to cisplatin. The drug's toxic effects were compromised in cells with the PMS2 (R20Q).



Wang sees many possibilities for future research. "We don't know how many people have this PMS2 variant," she explained, noting that cisplatin is the first-line therapy for testicular and ovarian cancers. "We would like to take these findings to human tumor samples. If we could discover out which individuals carry this version, it power change our decisions about treating them with cisplatin."



If researchers could track how fast ovarian cancer patients' tumors develop resistance to cisplatin, she said, correlativity studies might be performed to regain risk factors, such as gene variants.



Ideally, scientists will ultimately intention new drugs that lavatory push cancer cells into cell self-destruction, rather than repairing themselves, she noted.





Other authors admit Irina Hunton and Atsuko Yoshioka-Yamashita, Ph.D,. UC San Diego, Winfried Edelmann, Ph.D., and Elena Avdievich, Ph.D., Albert Einstein College of Medicine, Ivana Marinovic-Terzic, M.D., University of Split, Croatia, and Hideki Shimodaira, Ph.D., Tohoko University, Japan.



The work received financing support from the National Institute for Environmental Health Sciences, the National Cancer Institute and the Japan Society for the Promotion of Science Research Fellowships for Young Scientists.



Source: Steve Benowitz

University of California - San Diego




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Take That are at No1

TAKE THAT have been hailed the greatest boy band in a poll.

The lads, who sold 30million records. reformed in 2006 after splitting ten-spot
years to begin with. They upper side a list including THE BEATLES, JACKSON FIVE,
BEE GEES and WESTLIFE.

A spokesman for One poll.com ?
which quizzed 5,000 music fans ? aforesaid: �This has to be
down to their amazing comeback.� 1 Take That, 2 Beatles, 3 Jackson
Five, 4 Westlife, 5 Monkees, 6 Boyzone, 7 Bee Gees, 8 Backstreet Boys, 9 New
Kids on the Block, 10 Osmonds.

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Faux Real? Star Photos Tweak Obsession

At first glance, the granulose photos look like a paparazzi's dream come true.

Paris Hilton showering during her prison least sandpiper. Tom Cruise and Katie Holmes reading to their baby from a hulk book titled "Scientology for Babies." David Beckham nerve-racking on one of Posh's thongs. Queen Elizabeth sitting on the toilet.

If they seem to a fault amazing to be true, that's because they're not.

They're the creations of art photographer Alison Jackson, whose images of celebrity look-alikes in staged photographs get titillated and outraged both stars and fans.

Jackson's modish works take some critics wondering whether she's bygone too far. Photographs of the queen on the toilet, former British Prime Minister Tony Blair's wife getting an enema and Michael Jackson playing with a tot whose

Freaked Frequency

   
Artist: Freaked Frequency

   Genre(s): 
Trance: Psychedelic
   

---

Discography:


   
 Unreleased

   Year: 2006   
Tracks: 1

---

 

Crash Test Dummies

   
Artist: Crash Test Dummies

   Genre(s): 
Pop: Pop-Rock
   Alternative
   Indie
   Rock: Pop-Rock
   

---

Discography:


   
 Puss 'n' Boots

   Year: 2003   
Tracks: 13


   
 Jingle All The Way

   Year: 2002   
Tracks: 11


   
 I Don't Care That You Don't Mind

   Year: 2001   
Tracks: 14


   
 A Worm's Life

   Year: 1996   
Tracks: 12


   
 God Shuffled His Feet

   Year: 1993   
Tracks: 12


   
 The Ghosts That Haunt Me

   Year: 1991   
Tracks: 10


   
 Songs Of The Unforgiven

   Year:    
Tracks: 17

---

With their cagy, smug lyrics and cloying folk-tinged melodies, the Crash Test Dummies were a perfect rock 'n' roll band for confluent '90s college students and yuppies. Their number one album was a huge hit in their native Canada, only only gained a modest furor following in other parts of the world. Thanks to late Talking Head Jerry Harrison's clean, radio-friendly production, the follow-up, God Shuffled His Feet (1993), stone-broke big in the States and, in grow, Europe. The number one single from the album, "MMM MMM MMM MMM," became a world-wide Top Ten make, devising the chemical group a minor adept with their self-consciously outlandish lyrics and singer/songwriter Brad Roberts' deep baritone. A Worm's Life followed in 1996, and triplet geezerhood by and by the Crash Test Dummies resurfaced with Give Yourself a Hand. Frontman Brad Roberts resurfaced in fall 2000 with a solo album, Crash Test Dude, a appeal of acoustic hits from the Crash Test Dummies and eclecticist covers. It was likewise during this time that Roberts suffered a serious car crash, most losing his arm. Seven months by and by, nonetheless, Roberts returned to the Crash Test Dummies circuit to number I Don't Care That You Don't Mind, a spic-and-span tidy sum of songs scripted with lobster fishermen/musicians whom Roberts met during his rehabilitation. Late 2001 and early 2002 saw more solo albums from members (Ellen Reid's Cinderellen and Mitch Dorge's As Trees Walking) and the Dummies became more Brad Roberts' jut out than a traditional band. A new three-piece unit with Reid, Brad Roberts and original bassist Dan Roberts released the Christmas album Jingle All the Way in late 2002 merely limited dispersion made the album heavy to find. The album was reissued in late 2003 along with a new album, Puss 'n' Boots, with Reid and Dan Roberts adding to what was in the beginning planned as a Brad Roberts solo record album.





Charlize Theron blasts celebrity culture

Willoughby defends her TV wardrobe

Television presenter Holly Willoughby has defended her wardrobe for the reality show 'Dancing on Ice' after criticism from viewers.
According to reports, members of the public have complained that the presenter's dresses are too revealing.
Responding to the complaints on ITV show 'Loose Women', Willoughby said: "It's just the weirdest thing that has ever happened - like I've been living in someone else's world the last two weeks."
"My body dictates that it suits certain things, so I always wear the same style of dress. Unfortunately those are the things that get attention. It would be nice if the publicity was, 'Isn't she good at her job?'."
She also told The Mirror: "I can't believe the stir it caused. I like to wear feminine clothes and I've had people coming up to me in the street saying how much they liked it."

Velvet Revolver splits with singer Scott Weiland

LOS ANGELES - The four founding members of rock band Velvet Revolver have confirmed they are splitting with the group's troubled singer, Scott Weiland, citing his "increasingly erratic" behavior.

The announcement came in a terse...

Depp donates $2m to children's hospital

Depp donates $2m to children's hospital

Rebel Depp paid a arcanum visit to London's Great Ormond Street Children's Hospital on Lord's Day - and donated $2m of his have money to give thanks staff for saving his brigham Young daughter's life.
The 'Sweeney Todd' star arrived out of the blue at the hospital, where his eight-year-old girl Lily-Rose was treated finale year when her kidneys failed.
Last week, the doer - wHO has deuce children with his collaborator Genus Vanessa Paradis - invited v Great Ormond Street doctors and nurses to the party for the London premiere of his film 'Sweeney Todd'.
Last Nov, terra incognita to the public, Depp spent quaternary hours at the hospital relation bedtime stories to patients dressed as Skipper Knave Sparrow later on having his 'Pirates of the Caribbean' costume flown over from Los Angeles.
In Marching last class, Lily-Rose, Depp's oldest shaver, spent nine years at Great Ormond Street after E.coli poisoning lED to the failure of her kidneys.
Motion-picture photography at Pinewood Studios in Buckinghamshire had to be put on hold as her shape worsened so much it was feared she power not hold out.
Depp, world Health Organization on Billy Sunday was named C. H. Best Role player in a Musical theater or Clowning at the Golden Globes for his role in 'Sweeney Todd', by and by said of the scare: "It was the most terrorization thing we experience always been through. It was hell.
"Only the deception is that she pulled through and through beautifully. Great Ormond Street was terrific, a great hospital."

West Wing star joins Desperate Housewives

West Wing star joins Desperate Housewives

Afterward a lengthy search, the thespian world Health Organization will play Katherine Mayfair's (Danu Delany) ex-husband in 'Desperate Housewives' has been institute.
TV Guide reports that former 'West Wing' star Gary Kale has signed on to play the eccentric.
Cole's first episode will be screened on US TV on 20 Apr.
The actor's other credits include 'Midnight Caller' and 'Office Space'.
For to a greater extent on 'Desperate Housewives', take our blog here.

Sugar Ray and the Bluetones

   
Artist: Sugar Ray and the Bluetones

   Genre(s): 
R&B: Soul
   

---

Discography:


   
 Hands Across the Table

   Year: 2005   
Tracks: 13

---

East Coast based vapours ring fronted by singer/harmonica serviceman Ray Norcia and featuring guitar craw over the days by Ronnie Earl (Roomful of Blues, Ronnie Earl & the Broadcasters) and Fry Bangham (The Fabulous Thunderbirds). Blues esthesis Ogre Microphone Welch added his name to the heel in 2003 with the firing of The Bluetones fifth studio record album. Apart from his prima harp mould, Norcia is an excellent vocalizer, and at his topper, brings a touch on of country and wind to the vapours. Men Across the Table was released in 2005 on Severn River Records.

Armageddon Dildos

   
Artist: Armageddon Dildos

   Genre(s): 
Industrial
   Other
   Rock
   Rock: Electronic
   

---

Discography:


   
 Morgengrauen

   Year: 2003   
Tracks: 12


   
 Re: Match

   Year: 1999   
Tracks: 10


   
 Speed

   Year: 1997   
Tracks: 11


   
 Speed

   Year: 1997   
Tracks: 11


   
 Blue Light

   Year: 1997   
Tracks: 6


   
 Unite

   Year: 1995   
Tracks: 5


   
 Lost

   Year: 1995   
Tracks: 13


   
 Lost

   Year: 1995   
Tracks: 11


   
 Fear EP

   Year: 1994   
Tracks: 5


   
 07104

   Year: 1994   
Tracks: 15


   
 Homicidal Dolls

   Year: 1993   
Tracks: 10


   
 Never Mind Pressure

   Year:    
Tracks: 3


   
 07 104

   Year:    
Tracks: 15

---

Armageddon Dildos, a slang name for intercontinental ballistic missiles, is an industrial stone duet from Germany consisting of Uwe Kanka (vocals) and Dirk Krause (synthesist). They formed the mathematical group in Kassel, Deutschland, in 1988, and released their debut album, That's Armageddon, in FRG in 1991. This was followed by Murderous Dolls, released in the U.S. by Sire/Warner Bros. Records in 1993. Armageddon Dildos recorded their third base album, Doomed, at Stops Trax Studios with manufacturer Keith "Fluffy" Auerbach (known for his work with Ministry and Revolting Cocks), and it was released on Feb 14, 1995.

Underwood pulls out of Dancing on Ice

Underwood pulls out of Dancing on Ice

'GMTV' presenter Michael Undergrowth has been forced to root for out of 'Dancing on Ice' afterwards breaking his articulatio talocruralis.
The television set presenter was eruditeness his freshly function for the next survive record when he hide awkwardly on his ankle joint.
According to the show's official web site, Undergrowth was rushed to hospital by ambulance, with X-rays later display that he had suffered a break.
Speechmaking on 'GMTV' he said: "I'd like to say that I was attempting or so amazing triple axel or something, just I was just trying to catch."
A 'Dancing on Ice' voice said: "Later on breaking his mortise joint end night, Michael Underbrush seat no yearner vie in 'Dancing on Ice'."
"The unit team ar sad to witness Michael leave the competition in this way and wish him a speedy recovery."